DCA: Divide-and-Conquer Multiple Sequence Alignment - Welcome

Divide-and-Conquer Multiple Sequence Alignment (DCA) is a program for producing fast, high quality simultaneous multiple sequence alignments of amino acid, RNA, or DNA sequences. The program is based on the DCA algorithm, a heuristic approach to sum-of-pairs (SP) optimal alignment that has been developed at the FSPM over the years 1995-97. The latest description on DCA can be found in: J. Stoye, Multiple Sequence Alignment with the Divide-and-Conquer Method, Gene 211, GC45-GC56, 1998.

Note: Any process using more than 500 Mbytes of memory on our server is stopped automatically. If you want to run DCA on larger sequence families, you should download DCA and install it locally.

• Simultaneous Multiple Sequence Alignment
• Simultaneous versus Iterative Multiple Alignments
• The DCA Algorithm
• The FDCA Heuristic
• Parameters of DCA
• Example DCA Alignment