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An DIALIGN 2.1 - Based and Manually Improved Alignment of 111 Serpin Sequences
from SWISSPROT and GENBANK
(see table for access numbers and phenotype names)
Average sequence length: 405.118
The 111 serpin sequences studied in [Ragg et al.,2000] and in
[Atchley et al.,2000], we have grouped as follows:
|
| Group |
Sequence type |
|
| 1 (Vertebrate) |
Ovalbumin-type |
1-16 |
| 2 (Vertebrate) |
Alpha1-antitrypsin-type |
17-64 |
| 3 (Vertebrate) |
PAI1-type |
65-76 |
| 4 (Vertebrate) |
Alpha2-antiplasmin-type |
77-84 |
| 5 (Vertebrate) |
AntithrombinIII-type |
85-88 |
| 6 (Vertebrate) |
Heatshock-Protein-type |
89-91 |
| 7 (Virus) |
Viral |
92-101 |
| 8 (Plant) |
Barley protein Z |
102 |
| 9 (Insect) |
Insect |
103 |
| 10 (Insect) |
Insect |
104-106 |
| 11 |
Nematode |
107-109 |
| 12 |
Horseshoe Crab |
110-111 |
|
|
Please note that the number of stars (*) below each column indicates the
amount of trust one should associate with that column, and that only
upper-case letters are considered to be aligned. The core of the
serpin domain - essentially the columns with at least three stars - can
be found on pages 8-9, 12-13 and 15-18.
For more information on DIALIGN 2.1, have a look at the user guide
Note also that, according to GENE 227 (1999) 241-248, HSP47_HUMAN is a
pseudogene (also called pshsp47) and that CBP2 appears to be the only
functional collagen-binding protein in humans.
Numbers (below) denoted by
1, 10, 20, ...
| | |
count sites according to the amino acid sequence of mature human
alpha1-antitrypsin.
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