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Author: S. Janssen

Covariance models (CMs), as defined by Sean Eddy, do not reward insertions of valid base-pairs or complete sub-structures relative to the one consensus secondary structure. Nevertheless, some families, e. g. tRNA, contain minorities with additional informative sub-structures, which are crashed by the majority during formation of one consensus secondary structure.

Ambivalent Covariance Models (aCMs) are our prototypic suggestion to extend CMs with more than one consensus structure.

tRNA example evaluation.

built on June 25 2015 (18:c9e1561533b7)